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Sandra TorresTorres has a rare disorder called Laron syndrome that is caused by a genetic mutation. “This is how powerful this mutation seems to be.”What is Laron syndrome? Laron syndrome is a recessive gene, so only those who receive a copy from each parent will be affected. The condition leads to extreme obesity, a trigger for diabetes, heart disease, cancer and other diseases. While technically overweight at 100 pounds (45.4 kilograms), she was in good health, with no signs of diabetes or heart disease.
Persons: Paola Castro Torres, ” Torres, Torres, , ” Nathaly Paola Castro Torres, Sandra Torres Torres, , Valter Longo, Longo, Laron, Jaime Guevara, Aguirre, Guevara, ” Longo, ” Guevara, Andrew Freeman, Freeman, ” Hope, it’s Organizations: CNN, gerontology, University of Southern, of Endocrinology, Laron, Jewish Health Locations: Los Angeles, Quito, Ecuador, University of Southern California, Israel, Yemen, East, United States, Croatia, Ireland, Denver
Crafting Shoes Never Meant to Be Walked In
  + stars: | 2024-04-22 | by ( Jessica Roy | ) www.nytimes.com   time to read: +1 min
Last week at the Venice Biennale, the milliner Giuliana Longo wore gold earrings in the shape of hats as she showed off a hat sculpture made of natural agave. Ms. Longo, who has worked as a milliner since 1969, said through a translator that she fell in love with hats because “if you wear a hat, you become a different person.”Dotted with 500 “pebbles,” each hand stitched to the fabric, the hat was in fact not just a hat but a tribute to a shoe: the Tod’s Gommino driving shoe, a hand-stitched loafer in leather or suede with rubber pebbles on the bottom and back that make it look a bit like a soft, chic cleat. Tod’s, the Italian leather goods and fashion company, had assembled 11 Venetian craftsmen to interpret the Gommino using their own tools and artistry. The works, created by Venetian glassblowers, mask makers and other artisans, were exhibited at a cocktail party on April 19. At an airy warehouse across the canal from the Italian Pavilion, craftspeople stood proudly by their work.
Persons: Giuliana Longo, Longo Organizations: Venice Biennale Locations: Venice, Venetian
Valter Longo has been studying longevity in Italy for nearly 20 years, but having grown up in regions like Molochio, Calabria, he would say he's been interested in how to live longer basically all of his life. In 1989, Longo officially started researching what it takes to make it to age 100 and beyond. Now, he's the director of the Longevity and Cancer Laboratory at the IFOM Institute of Molecular Oncology in Milan, Italy. Longo is also the director of the Longevity Institute of the Leonard Davis School of Gerontology at the University of Southern California-Los Angeles. Here's what Longo says is the best way to eat for longevity.
Persons: Valter Longo, he's, Longo, Dan Buettner Organizations: Cancer Laboratory, IFOM, Molecular Oncology, Longevity, Leonard Davis School of Gerontology, University of Southern, University of Southern California -, Longo's Locations: Italy, Molochio, Calabria, Milan, University of Southern California, University of Southern California - Los Angeles, Sardinia
Intermittent fasting diet plans, meal kits, fitness trackers, and biological age tests can all offer something to busy people who want to feel in control. More than one in 10 Americans (12%) tried intermittent fasting in 2023, according to one food and beverage industry-backed survey. The business of intermittent fasting phone apps is blossoming and is on track for more growth in the next five to 10 years. There are many ways to do intermittent fasting — from skipping breakfast to whole days without foodPeople have been fasting for as long as people have been people. AdvertisementThe case against fasting to lose weight and live longerFirefighters in San Diego tried intermittent fasting out during the pandemic, with good results.
Persons: , Chris Hemsworth, Podcaster Andrew Huberman, Hugh Jackman, Dwayne, Johnson, Terry Crews, It's, Sam Altman, biohacking, Dave Asprey, Gary Vaynerchuk, Bryan Johnson, Jack Dorsey, it's, Hippocrates, Daniel Belsky, There's, Satchidananda Panda, I've, Krista Varady, Dr, Peter Attia, you've, Satchidananda, He's, Randy Shropshire, nix, Valter Longo, Longo, Belsky, Stephen Kritchevsky, Mark Cucuzzella, Nir Barzilai, Nir Barzilai Nir Barzilai, Barzilai, Panda, That's, Cucuzzella Organizations: Service, Business, Columbia University, 16ers, Salk Institute for Biological Studies, University of Illinois, Getty, Cancer, gerontology, USC, Firefighters, Wake Forest University, West Virginia University School of Medicine, Institute for Aging Research, Albert Einstein College of Medicine Locations: Greece, Chicago, San Diego, New York
Most members of the band subscribed to a live-fast-die-young lifestyle. Now, decades after Dr. Longo dropped his grunge-era band, DOT, for a career in biochemistry, the Italian professor stands with his floppy rocker hair and lab coat at the nexus of Italy’s eating and aging obsessions. “For studying aging, Italy is just incredible,” said Dr. Longo, a youthful 56, at the lab he runs at a cancer institute in Milan, where he will speak at an aging conference later this month. Italy has one of the world’s oldest populations, including multiple pockets of centenarians who tantalize researchers searching for the fountain of youth. “It’s nirvana.”Dr. Longo, who is also a professor of gerontology and director of the U.S.C.
Persons: Valter Longo, Longo, , Dr Organizations: West Coast, gerontology, Longevity Locations: Italian, Italy, Milan, California
AdvertisementFollowing a diet that mimics fasting for five days a month appeared to reverse people's biological age by two and a half years on average in a study. These factors can be used to measure biological age, the authors of the study published January 20 in Nature Communications, said. While chronological age refers to how many years someone has been alive, biological age is a measure of how well cells and tissues are functioning. On day one of the FMD, participants ate around 1,100 calories, and around 720 on days two to five. Cultivating a sensible exercise habit could achieve the same or even better results, Clancy said, and is maintainable into older age.
Persons: Valter Longo, USC Leonard Davis, Longo, Levine, Clare Bryant, David Clancy, Clancy Organizations: USC Leonard, USC Leonard Davis School of Gerontology, Cleveland Clinic, Nature Communications, Cambridge University, UK, Lancaster University, BMI
The decision is an early win for the Biden administration as it grapples with a flurry of other legal challenges that drugmakers have filed against the Medicare drug price negotiations. The judge's ruling won't end the legal battle over the policy, which could end up at the Supreme Court. A slate of major companies with drugs selected for negotiations, including J&J, Merck , and Bristol Myers Squibb , have filed separate lawsuits challenging the constitutionality of the price talks. The suit also argued that the price talks violate the Eighth Amendment because they include a "crippling" excise tax aimed at forcing drugmakers to accept the government-dictated price of medicines. The groups also argued that the price talks violate due process by denying pharmaceutical companies and the public input on how Medicare negotiations will be implemented.
Persons: Biden, drugmakers, Judge David Ezra of, Ezra, NICA's, Nicole Longo, PhRMA, Eli Lilly, Johnson, NICA Organizations: U.S . Department of Health, Human Services, Supreme, Medicare, Western, Western District of Texas, Pharmaceutical Research, Manufacturers of America, Global Colon Cancer Association, National, Center Association, CNBC, Pfizer, Johnson, Merck, Bristol Myers Squibb, Chamber of Commerce, Department of Health, Department of Justice Locations: Washington ,, Western District, PhRMA, Ohio
A board displaying stock prices is adorned with the Australian Securities Exchange (ASX) logo in central Sydney, Australia, February 13, 2018. REUTERS/David Gray/File Photo Acquire Licensing RightsNov 20 (Reuters) - Australian bourse operator ASX Ltd (ASX.AX) said on Monday it entered a deal with TATA Consultancy Services (TCS) <TCS.NS> to design and replace its trading, clearing and settlement system, after months of backlash since pulling a blockchain-based overhaul of the system last year. The estimated cost for the first release of the Clearing House Electronic Subregister System (CHESS) project is between A$105 million ($68.33 million) and A$125 million, to be incurred over multiple years, ASX said. ASX's initial attempt to overhaul CHESS earned rebuke from the Australian Securities and Investments Commission (ASIC) and Reserve Bank of Australia, with the regulators demanding more thorough reporting on plans to update the 30-year-old software. ($1 = 1.5366 Australian dollars)Reporting by Himanshi Akhand in Bengaluru Editing by Chris Reese and Diane CraftOur Standards: The Thomson Reuters Trust Principles.
Persons: David Gray, Joe Longo, Helen Lofthouse, Himanshi, Chris Reese, Diane Craft Organizations: Australian Securities Exchange, REUTERS, TATA Consultancy Services, Australian Securities and Investments Commission, Reserve Bank of Australia, Accenture, TCS, Thomson Locations: Sydney, Australia, Australian, Bengaluru
A board displaying stock prices is adorned with the Australian Securities Exchange (ASX) logo in central Sydney, Australia, February 13, 2018. That will, however, take time, with the overhaul now expected to finish in 2029, some 13 years after it began. It also prompted the Australian Securities and Investments Commission (ASIC) to open an investigation into the exchange's disclosures about the project. ASX said it expected the first stage of the new project, clearing software, to cost between A$105 million and A$125 million with delivery around 2026. The cost and timing of the settlement and other software will be decided in 2024.
Persons: David Gray, Tim Whiteley, Joe Longo, Longo, Byron Kaye, Himanshi, Edwina Gibbs Organizations: Australian Securities Exchange, REUTERS, Tata Consultancy Services, New, Australian Securities and Investments Commission, Thomson Locations: Sydney, Australia, India, Finland, Canada, New York, Bengaluru
CNN —Lyon head coach Fabio Grosso was left “seriously injured” and with pieces of glass stuck in his head after projectiles were thrown at the soccer team’s bus ahead of a Ligue 1 game against Marseille on Sunday. “Coach Fabio Grosso and his assistant Raffaele Longo were directly hit and seriously injured in the face during this attack,” the club statement said. “We had a coach who’s got blood coming out of his head, he’s got pieces of glass stuck in his head, and he must have taken some contact to his head,” Lyon president John Textor told Prime Video Sport France about Grosso’s condition. Darmanin also said that, as well as throwing projectiles at the Lyon team’s bus, Marseille fans had also attacked opposing supporters. Fans wait to see if the match between Marseille and Lyon will go ahead.
Persons: CNN —, Fabio Grosso, , , Grosso, Raffaele Longo, Longo, Christophe Simon, Lyon, who’s, he’s, ” Lyon, John Textor, I’ve, Gérald Darmanin, Darmanin, Amélie, Castéra Organizations: CNN, CNN — Lyon, Ligue, Marseille, Marseille’s Stade Velodrome, Olympique Lyonnais, Lyon, Stade Velodrome, Getty, French, Sport France, BFMTV, Nazi Locations: Lyon, AFP, Marseille
Marseille match against Lyon called off after team bus attacked
  + stars: | 2023-10-29 | by ( ) www.reuters.com   time to read: +2 min
Oct 29 (Reuters) - Sunday's Ligue 1 match between Olympique de Marseille and Olympique Lyonnais was called off after Lyon's team bus was pelted with stones, injuring coach Fabio Grosso, as the players made their way to the Stade Velodrome. Sky Italia footage showed damage to two bus windows and Grosso being led into the stadium by two assistants. Italian media said Grosso suffered injuries to his scalp and face. "He can't hold a conversation, he had shards of glass in his face," Lyon's club president, John Textor added. "Because of a handful of thoughtless people, the party planned for this evening has been ruined, and 65,000 fans have been deprived of attending a football match," the club added.
Persons: Fabio Grosso, Grosso, John Textor, Lyon, Francois Letexier, Fabio Grosso's, Amelie Oudea Castera, Raffaele Longo, Tommy Lund, Kate Entringer, Hugh Lawson, Clare Fallon Organizations: Ligue, Olympique de Marseille, Olympique Lyonnais, Stade Velodrome, Sky, OL, French Professional League, Lyonnais, Marseille, Thomson Locations: Marseille, Gdansk, Paris, Lincoln
Patients with private health insurance aren't likely to see a drop in costs from the negotiations. Longo said the price-setting provisions will drive research and investment away from treatment options for Medicare patients. If drug companies won't come to the negotiating table to lower drug prices paid by private insurers, those insurers could take the companies' drugs off their lists of covered medications. Or, if private insurance companies don't negotiate drug prices down for their patients, patients in some cases could seek out different insurance. "These are not full solutions, but they are the beginning of cracks in the facade" of drug companies' constant price hikes, Feldman said.
Persons: Biden, Juliette Cubanski, Jeffrey Davis, Davis, Richard Frank, , Nicole Longo, Longo, it's, — aren't, Robin Feldman, Feldman, Cuban's Organizations: Medicare, Healthcare, Morning, Centers, Services, Congressional, McDermott, Consulting, Brookings Schaeffer Initiative, Health, Pharmaceutical Research, Manufacturers of America, PhRMA, University of California Law School, Costco, Pharmaceutical Locations: Lower
Insider Today: Tech's biggest lie
  + stars: | 2023-09-18 | by ( Dan Defrancesco | ) www.businessinsider.com   time to read: +9 min
In recent years, some members of Congress have lacked a basic understanding of technology, let alone something as complex as generative AI. Marc Benioff spent much of the annual Dreamforce conference sounding the alarms on how untrustworthy generative AI is right now. Marc Benioff spent much of the annual Dreamforce conference sounding the alarms on how untrustworthy generative AI is right now. It's International Equal Pay Day. The UN General Assembly created this day in 2019 with "equal pay for work of equal value" in mind.
Persons: Mark Sumersett, isn't, Simon Simard, Daron Acemoglu, Insider's Aki Ito, Acemoglu, hasn't, Aki, It's, Nat Friedman, Rebecca Zisser, Peter Brown, Marc Benioff, Salesforce, Greg Johnson, Gary Reyes, Janette Beckman, Getty, Johnny Nunez, Lynn Goldsmith, Dakarai Akil, Tupac, Akon, Sean Kingston, Gucci Mane, There's, Carly Pearce, Valter Longo, Dan DeFrancesco, Naga Siu, Hallam Bullock, Lisa Ryan Organizations: Service, MIT, Renaissance Technologies, Bloomberg Beta, McAfee, Oakland Tribune Staff, Interscope Records, Academy of Country, FOX, UN, Assembly, Getty Locations: Wall, Silicon, New York City, San Diego, London, New York
That marked the 10th straight season in which at least two Big Ten teams ranked in the top 10 in total defense. The last time the Big Ten had two teams rank in the top 15 in total offense was 2014. Washington ranked second, USC third, UCLA fourth and Oregon sixth nationally in total offense just last season. The arrivals of Harrell and Longo suggest Big Ten teams might start throwing the ball more often. “I definitely think football as a whole has kind of shifted to that spread offense, West Coast offense type of deal from Coach Leach,” Williams said.
Persons: , Graham Harrell, , Luke Fickell, ” Fickell, Ben Scott, CJ Williams, Scott, ” Scott, Harrell doesn’t, ” Harrell, they’ve, Harrell, Mike Leach’s, Phil Longo, Longo’s, Sam Howell, Drake Maye, Longo, P.J, Fleck, Barry Alvarez’s, Tanner, Coach Leach, ” Williams, Eric Olson, Dave Campbell, Michael Marot Organizations: Big, Purdue, USC, Iowa, Ohio State, Washington, UCLA, Oregon, Big Ten, Arizona, Coast, West Coast, Texas Tech, North, Drake Maye . Ohio State, Nebraska, Gophers, Badgers, Buffalo, SMU, West, AP College Football, AP Sports, AP Locations: MADISON, Wis, Southern California, UCLA, Oregon, Washington, , Illinois, Michigan, Minnesota, , Wisconsin, Wisconsin, Indiana, Big Ten . Nebraska, Arizona State, North Carolina, Drake Maye . Ohio, ” Minnesota
June 22 (Reuters) - Midfielder Annalie Longo is in a race to recover from a serious knee injury and make New Zealand's Women's World Cup squad, but will gladly endure pain to play in front of home fans if selectors back her. The 31-year-old tore her anterior cruciate ligament (ACL) and medial ligaments in her left knee against Mexico last September but has returned to training with Jitka Klimkova's Football Ferns to push for a fourth World Cup appearance. "For me it's kind of a do-or-die, risk-reward thing," she told Reuters from training. "I think just the nature of the time-frame there is going to be a bit of uncomfortable pain in the knee but it's all to play at a home World Cup. Drawn in Group A, New Zealand will also play Philippines and Switzerland in the preliminaries, looking for their first ever win at a World Cup and to fulfil their goal of making the knock-out phase.
Persons: Annalie Longo, Jitka, Longo, I've, I'm, Olivia Chance, Ria Percival, Klimkova, shrugged, Ian Ransom, Muralikumar Organizations: Mexico, Jitka Klimkova's Football Ferns, Norway, Reuters, Ferns, New Zealand, Iceland, New Zealand Football, Thomson Locations: Eden, Czech, New Zealand, Philippines, Switzerland, Melbourne
What to Know About Eclampsia
  + stars: | 2023-06-13 | by ( Alisha Haridasani Gupta | ) www.nytimes.com   time to read: +1 min
The report identified complications of childbirth as the cause of death, listing eclampsia and respiratory distress as possible factors. “Eclampsia occurs in somewhere between one to 10 in 10,000 pregnancies,” said Dr. Joanne Stone, the head of the department of obstetrics, gynecology and reproductive science at the Icahn School of Medicine at Mount Sinai. Research has suggested that rates of hypertensive disorders of pregnancy — including pre-eclampsia, eclampsia and gestational hypertension — have been on the rise, and increased during the Covid-19 pandemic. What is eclampsia? There can be other causes of seizures during pregnancy, but it’s considered eclampsia “until proven otherwise” through lab tests, including neurological tests, Dr. Longo said.
Persons: Tori Bowie, , Joanne Stone, Monica Longo, Eunice Kennedy, Stone, it’s, Longo Organizations: The New York Times, Olympic, Icahn School of Medicine, Research, National, of Child Health, Human, National Institutes of Health Locations: Mount Sinai
People look at the cars in the Cariad booth at this year’s Consumer Electronics Show in Las Vegas. Photo: Jacob Kepler for The Wall Street JournalBERLIN— Volkswagen Chief Executive Officer Oliver Blume , in his first major restructuring move since becoming chief last year, will replace the management of the company’s struggling software unit after it caused delays to new model launches, according to a person familiar with the matter. Dirk Hilgenberg , head of the unit called Cariad, finance chief Thomas Sedran , and Lynn Longo, a Michigan native who serves as Cariad’s chief technology officer, could be ousted as early as this week, possibly after VW’s planned shareholder meeting on Wednesday, the person said.
Cariad, which had a booth at this year’s Consumer Electronics Show, held the company’s brands back from moving faster. Photo: Jacob Kepler for The Wall Street JournalBERLIN— Volkswagen Chief Executive Officer Oliver Blume , in his first major restructuring move since becoming chief last year, is expected to replace the management of the company’s struggling software unit after it caused delays to new model launches, according to people familiar with the matter. The decision to remove Dirk Hilgenberg , head of the unit called Cariad, finance chief Thomas Sedran , and Lynn Longo , a Michigan native who serves as Cariad’s chief technology officer, could be announced as early as this week, possibly before VW’s planned shareholder meeting on Wednesday, the people said.
Since then, various plans, including a short-lived idea for a tunnel, have come and gone – like water under the bridge. If built, the bridge across the Straits of Messina would span two miles (3.2 kilometers) and would be the longest suspension bridge in the world. When Salvini became transport minister, he made it his priority, betting his legacy on the bridge. “The bridge over the Strait of Messina is a project that can break ground immediately. The recent arrest of Cosa Nostra boss Matteo Messina Denaro after 30 years on the lam in Sicily represented a victory.
Berkshire Hathaway faces high inflation, rising rates, and a potential recession and credit crunch. Warren Buffett's company will weather the storm and scoop up the bargains that emerge, experts say. Experts say Berkshire's ample cash reserves, strong brands, and prudent management will enable it to comfortably navigate a harsh economic environment. "Shareholders who plan on holding Berkshire for years into the future should hope for a near-term bear market in stocks. Brian Gongol, longtime Buffett follower and Berkshire shareholder:"It's better to be in Berkshire's shoes during challenging times than during a boom.
Binance's Australian derivatives license was canceled at the crypto exchange's own request, the Australian Securities & Investments Commission said Thursday, after the regulator had begun a "targeted review of Binance" in February. Binance's exchange token was down just under 0.5% Thursday morning. Binance's regulatory scrutiny has been mounting in recent weeks and months. An apparently inadvertent compliance issue led to the Australian regulatory probe. Australia's top securities regulator has had a challenging relationship with the crypto industry in recent months, pursuing enforcement actions against several firms which the regulator alleges have violated Australian law.
ASIC on Thursday cancelled the Australian financial services licence of Oztures Trading Pty Ltd, trading as Binance Australia Derivatives (Binance), in response to a request from the company. “Our targeted review of these matters is ongoing, including focus on the extent of consumer harms.”The financial services licence authorised Binance to issue derivatives and foreign exchange contracts. Noting many cryptocurrency products and services are not regulated by ASIC, Longo said the regulator supported a "regulatory framework" for the asset class. Binance said in a statement it had decided to pursue a "more focused approach" in Australia after "recent engagement with ASIC". The world's largest cryptocurrency exchange is battling regulatory suits and probes around the world.
A United Airlines flight was grounded for several hours in Vermont on Sunday. A local NBC affiliate obtained audio of the plane's pilot discussing an apparent bomb threat. The Burlington airport was closed during the search and reopened around 7:30 p.m. local time. "A flight attendant just came up and said that a passenger found a note in the aft lav that said there was a bomb on board," the pilot can be heard saying. A spokesperson for United referred Insider to Republic Airways, which was operating the regional flight.
Peloton said Wednesday its net loss narrowed year over year, and, for the third quarter in a row, subscriptions revenue was higher than sales of the company's connected fitness products. The fitness equipment company's fiscal second quarter revenue beat Wall Street's expectations, but the company posted wider losses per share than expected. Connected fitness product sales, which are typically strong during Peloton's holiday quarter, dropped 52% year-over-year while subscription revenue jumped 22%. Gross margins for its connected fitness products were negative 11.2%, but gross margins for subscription sales were 67.6%. The company is also expecting connected fitness subscribers to be between 3.08 million and 3.09 million.
The Biden administration presented a plan on Wednesday to let the government negotiate drug prices. Trump, who once accused Big Pharma of "getting away with murder," could be president when drug prices fall. Gutting the prescription drug provision would come at a cost to the federal government. President Trump signed a series of four executive orders aimed at lowering prices that for prescription drugs in the United States. "There has been no bigger champion of lowering prescription costs and putting Americans first than President Trump," Steven Cheung, Trump's 2024 campaign spokesman, told Insider.
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